Cerebral Hemispheres 2

NEUROSCIENTIFICALLY CHALLENGED

NEUROSCIENCE MADE SIMPLER

2-Minute Neuroscience: Alzheimer's Disease

April 7, 2016


a coronal slice of a brain that has atrophied severely due to the effects of alzheimer's disease.

A coronal slice of a brain that has atrophied severely due to the effects of Alzheimer's disease.

In this video, I discuss Alzheimer's disease---the most common form of neurodegenerative disease. In addition to the widespread neurodegeneration that occurs in Alzheimer's disease, there are specific neurobiological abnormalities that appear in the brains of Alzheimer's disease patients. For example, clusters of a misfolded form of a protein called amyloid beta develop around neurons; the clusters are called amyloid plaques. Additionally, clusters of misfolded tau protein develop inside neurons; these clusters are called neurofibrillary tangles. The most common treatments for Alzheimer's disease are acetycholinesterase inhibitors, which are drugs that inhibit the breakdown of the neurotransmitter acetylcholine. Acetylcholine is thought to be important to healthy cognition, but acetylcholinesterase inhibitors have relatively modest effects on the symptoms of Alzheimer's disease.

YOUR BRAIN, EXPLAINED

Sleep. Memory. Pleasure. Fear. Language. We experience these things every day, but how do our brains create them? Your Brain, Explained is a personal tour around your gray matter. Building on neuroscientist Marc Dingman’s popular YouTube series, 2-Minute Neuroscience, this is a friendly, engaging introduction to the human brain and its quirks using real-life examples and Dingman’s own, hand-drawn illustrations.

  • Reading like a collection of detective stories, Your Brain, Explained combines classic cases in the history of neurology with findings stemming from the latest techniques used to probe the brain’s secrets. - Stanley Finger, PhD, Professor Emeritus of Psychological & Brain Sciences, Washington University (St. Louis), author, Origins of Neuroscience

  • An informative, accessible and engaging book for anyone who has even the slightest interest in how the brain works, but doesn’t know where to begin. - Dean Burnett, PhD, author, Happy Brain and Idiot Brain

  • Dingman weaves classic studies with modern research into easily digestible sections, to provide an excellent primer on the rapidly advancing field of neuroscience. - Moheb Costandi, author, Neuroplasticity and 50 Human Brain Ideas You Really Need to Know

  • ...a highly readable and accessible introduction to the operation of the brain and current issues in neuroscience... a wonderful introduction to the field. - Frank Amthor, PhD, Professor of Psychology, The University of Alabama at Birmingham, author, Neuroscience for Dummies